Antibiotic resistance in Enterobacteriaceae

Because modern versions tend to have a microbial foundation, eventual resistance to antibiotics is expected and typically surfaces within a few years after a new product becomes available. Resistance to carbapenem—especially in the Enterobacteriaceae—is especially aggressive, having moved away from natural resistance caused by drug efflux, membrane impermeability, and other factors. Mobilization and fixation of gene pools have become the primary drivers instead, making it trickier to monitor and control antibiotic resistance.